This study was conducted with the aim of identifying and structuring the factors affecting the internationalization of small and medium-sized businesses in creative industries. The research is applied in terms of purpose and exploratory-descriptive in nature with a mixed qualitative-quantitative approach. The research population consisted of academic and executive experts familiar with internationalization, small and medium-sized businesses, and creative industries, and 12 experts, including 7 academic experts and 5 executive experts, were selected purposefully. In the first stage, 46 factors were identified by reviewing the literature and then, using the experts' opinions, these factors were refined to 10 final factors including innovation and creative development capabilities, international marketing capabilities, digital transformation capacity, network capital, managerial capabilities, financial resources, learning and adaptation capabilities, intellectual property and brand identity management, institutional supports, and international competitive advantage. Structural-interpretive modeling was used to analyze the relationships between the factors, and MICMAC analysis was used to determine their influence and degree of dependence. The findings showed that managerial capability and international orientation of managers, institutional support and financial resources are the driving and underlying factors of the model. Innovation capabilities, international marketing, digital transformation, interorganizational relations, learning and intellectual asset management were considered as connecting factors. Also, international competitive advantage and market development performance were identified as dependent factors and the final outcome of the model. In summary, the internationalization of creative enterprises is a multi-level and systematic process whose success depends on the simultaneous interaction of management, institutions, resources, technology, learning and networking.